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See the reverse side of this notice to obtainproxy materials and voting instructions.*** Exercise Your Right to Vote ***Important Notice Regarding the Availability of Proxy Materials for theStockholder Meeting to Be Held on .You are receiving this communication because you holdshares in the above named company.This is not a ballot. You cannot use this notice to votethese shares. This communication presents only anoverview of the more complete proxy materials that areavailable to you on the Internet. You may view the proxymaterials online at or easily request apaper copy (see reverse side).We encourage you to access and review all of the importantinformation contained in the proxy materials before voting.Meeting InformationMeeting Type: For holders as of: Date: Time: Location:0000466774_1 R1.0.1.18CODEXIS, INC.CODEXIS, INC.200 PENOBSCOT DRIVEREDWOOD CITY, CA 94063Annual MeetingApril 21, 2020June 16, 2020June 16, 2020 9:00 AM PDTMeeting live via the Internet—please be sure to have the information that is printed inthe box marked by the arrow -> [xxxx xxxx](located on the following page)


Please Choose One of the Following Voting MethodsVote In Person: Many stockholder meetings have attendance requirements including, but not limited to, the possessionof an attendance ticket issued by the entity holding the meeting. Please check the meeting materials for any specialrequirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares.Vote By Internet: To vote now by Internet, go to Have the information that is printed in the boxmarked by the arrow available and follow the instructions.Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.How To Voteï§Before You VoteHow to Access the Proxy MaterialsProxy Materials Available to VIEW or RECEIVE:How to View Online:Have the information that is printed in the box marked by the arrow (located on thefollowing page) and visit: to Request and Receive a PAPER or E-MAIL Copy:If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge forrequesting a copy. Please choose one of the following methods to make your request:1) BY INTERNET: www.proxyvote.com2) BY TELEPHONE: 1-800-579-16393) BY E-MAIL*:* If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box markedby the arrow (located on the following page) in the subject line.ï§ï§0000466774_2 R1.0.1.181. Form 10-K 2. Notice & Proxy StatementRequests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investmentadvisor. Please make the request as instructed above on or before June 02, 2020 to facilitate timely delivery.


Voting items0000466774_3 R1.0.1.18The Board of Directors recommends you voteFOR the following:1. Election of three Class I directorsto hold office for a three-yearterm expiring at the 2023 annualmeeting or until their respectivesuccessors are duly elected.Nominees1a. Stephen Dilly, Ph.D. 1b. Alison Moore, Ph.D. 1c. Patrick Yang, Ph.D.The Board of Directors recommends you vote FOR proposals 2 and 3.2. To ratify the selection of BDO USA, LLP as the company’s independent registered public accounting firm for thefiscal year ending December 31, 2020.3. To approve, by non-binding advisory vote, the compensation of the company’s named executive officers asdisclosed in the Codexis, Inc. proxy statement in accordance with the compensation disclosure rules of theSecurities and Exchange Commission.NOTE: The proxies are authorized to vote in their discretion upon such other business as may properly come beforethe Annual Meeting or any adjournment or postponement thereof.


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