Annual report pursuant to Section 13 and 15(d)

Stock-based Compensation - Stock-Based Compensation Expense (Details)

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Stock-based Compensation - Stock-Based Compensation Expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Schedule of stock-based compensation expense      
Stock-based compensation $ 5,126 $ 4,620 $ 4,389
Research and development      
Schedule of stock-based compensation expense      
Stock-based compensation 935 953 1,201
Selling, general and administrative      
Schedule of stock-based compensation expense      
Stock-based compensation $ 4,191 $ 3,667 $ 3,188