Annual report pursuant to Section 13 and 15(d)

Collaborative Arrangements - Merck Sitagliptin Catalyst Supply Agreement (Details)

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Collaborative Arrangements - Merck Sitagliptin Catalyst Supply Agreement (Details) - USD ($)
1 Months Ended 12 Months Ended
Dec. 31, 2015
Feb. 29, 2012
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenue Benchmark | Collaborative Arrangement Concentration Risk          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Concentration risk, percentage     19.00% 22.00% 22.00%
Merck | Supply Agreement          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Term of collaborative research and development agreement   5 years      
Term of agreement extension 5 years        
Liability, revenue recognized     $ 0 $ 0 $ 1,300,000
Merck | Supply Agreement | Product revenue          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Liability, revenue recognized     $ 13,400,000 $ 15,100,000 $ 12,300,000