Annual report pursuant to Section 13 and 15(d)

Balance Sheets Details - Property and Equipment, net (Details)

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Balance Sheets Details - Property and Equipment, net (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Property, Plant and Equipment, Net, by Type [Abstract]      
Property and equipment $ 43,048 $ 39,533  
Less: accumulated depreciation and amortization (33,373) (33,251)  
Property and equipment, net 9,675 6,282  
Depreciation and amortization 1,950 1,570 $ 1,147
Laboratory equipment      
Property, Plant and Equipment, Net, by Type [Abstract]      
Property and equipment 25,468 23,561  
Equipment retired during period 1,800 1,000  
Leasehold improvements      
Property, Plant and Equipment, Net, by Type [Abstract]      
Property and equipment 10,785 10,804  
Computer equipment and software      
Property, Plant and Equipment, Net, by Type [Abstract]      
Property and equipment 3,192 3,016  
Office equipment and furniture      
Property, Plant and Equipment, Net, by Type [Abstract]      
Property and equipment 1,246 1,461  
Construction in progress      
Property, Plant and Equipment, Net, by Type [Abstract]      
Property and equipment $ 2,357 $ 691