Annual report pursuant to Section 13 and 15(d)

Balance Sheets and Statements of Operations Details (Property and Equipment, net) (Details)

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Balance Sheets and Statements of Operations Details (Property and Equipment, net) (Details) (USD $)
In Thousands, unless otherwise specified
Dec. 31, 2012
Dec. 31, 2011
Property, Plant and Equipment, Net, by Type [Abstract]    
Property and Equipment, Gross $ 50,822 $ 55,923
Less: accumulated depreciation and amortization (34,172) (31,747)
Property and equipment, net 16,650 24,176
Laboratory equipment [Member]
   
Property, Plant and Equipment, Net, by Type [Abstract]    
Property and Equipment, Gross 33,776 34,903
Leasehold improvements [Member]
   
Property, Plant and Equipment, Net, by Type [Abstract]    
Property and Equipment, Gross 4,388 13,058
Computer equipment and software [Member]
   
Property, Plant and Equipment, Net, by Type [Abstract]    
Property and Equipment, Gross 11,099 4,671
Office equipment and furniture [Member]
   
Property, Plant and Equipment, Net, by Type [Abstract]    
Property and Equipment, Gross 1,531 1,319
Construction in progress [Member]
   
Property, Plant and Equipment, Net, by Type [Abstract]    
Property and Equipment, Gross $ 28 [1] $ 1,972 [1]
[1] Construction in progress also includes equipment received but not yet placed into service pending installation.