Annual report pursuant to Section 13 and 15(d)

Selected Quarterly Financial Data (Unaudited) (Details)

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Selected Quarterly Financial Data (Unaudited) (Details) (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended 12 Months Ended
Dec. 31, 2012
Sep. 30, 2012
Jun. 30, 2012
Mar. 31, 2012
Dec. 31, 2011
Sep. 30, 2011
Jun. 30, 2011
Mar. 31, 2011
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Revenues:                      
Product $ 6,834 $ 7,140 $ 6,783 $ 15,167 $ 15,493 $ 12,199 $ 8,397 $ 12,932 $ 35,924 $ 49,021 $ 32,835
Collaborative R&D 1,078 18,569 15,868 14,612 17,296 19,201 17,385 17,486 50,127 71,368 70,196
Government awards 0 632 258 1,357 705 1,882 273 616 2,247 3,476 4,073
Total revenues 7,912 26,341 22,909 31,136 33,494 33,282 26,055 31,034 88,298 123,865 107,104
Costs and operating expenses:                      
Cost of product revenues 5,779 6,397 5,829 12,642 13,067 9,958 7,106 11,650 30,647 41,781 27,982
Research and development 10,594 14,191 15,650 16,349 15,548 16,786 14,965 13,750 56,785 61,049 52,405
Selling, general and administrative 7,286 7,909 6,789 9,395 9,782 8,871 9,276 9,013 31,379 36,942 33,841
Total costs and operating expenses 23,659 28,497 28,268 38,386 38,397 35,615 31,347 34,413 118,811 139,772 114,228
Loss before provision (benefit) for income taxes (15,712) (2,140) (5,442) (7,293) (5,123) (2,668) (5,205) (3,313) (30,587) (16,309) (8,157)
Net loss $ (15,539) $ (2,309) $ (5,519) $ (7,490) $ (5,297) $ (2,742) $ (5,040) $ (3,471) $ (30,857) $ (16,550) $ (8,541)
Net loss per share of common stock, basic and diluted (dollars per share) $ (0.41) $ (0.06) $ (0.15) $ (0.21) $ (0.15) $ (0.08) $ (0.14) $ (0.10) $ (0.84) $ (0.46) $ (0.35)
Weighted average common shares used in computing net loss per share of common stock, basic and diluted (shares) 37,581 [1] 37,118 [1] 36,296 [1] 36,057 [1] 35,965 [1] 35,919 [1] 35,685 [1] 35,116 [1] 36,768 35,674 24,594
[1] The full year net loss per share of common stock, basic and diluted, may not equal the sum of the quarters due to weighting of outstanding shares.